Active Rheumatoid Arthritis in Adults:
Polyarthritic Forms:
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Methox 2.5mg Tablet contains Methotrexate, classified as an Antimetabolite. It is prescribed for severe rheumatoid arthritis, including its polyarthritic forms, unresponsive to standard painkillers. Additionally, it is used for psoriasis, psoriatic arthritis, relapsed/refractory non-Hodgkin’s Lymphoma, and severe, active, juvenile idiopathic arthritis.
Methotrexate hampers the rapid reproduction of cells, acting as an anti-tumor agent. It also suppresses the immune system, alleviating symptoms of rheumatoid arthritis and psoriasis. Here are directions for use, potential side effects, and precautions:
May increase liver damage.
Consult your doctor.
Consult your doctor.
Avoid if feeling tired/dizzy.
Not recommended with disorders.
Not recommended with disorders.
Rheumatoid arthritis, Psoriatic arthritis, Psoriasis, Cancer
Common:
Uncommon:
Rare:
Methox 2.5mg Tablet is indicated for the treatment of psoriasis and rheumatoid arthritis, in patients who have tried other treatments but their illness have not improved.
Mechanism of Action of Methotrexate:
Folic Acid Antagonist:
Inhibition of DNA Synthesis:
Binding to Dihydrofolate Reductase:
Inhibition of Reduced Folate Formation:
Inhibition of Thymidylate Synthetase:
Resulting in Synthesis Inhibition:
Irreversible Binding:
By disrupting these essential processes, Methotrexate exerts its anti-tumor and immunosuppressive effects, making it effective in the treatment of various conditions, including cancer and autoimmune diseases like rheumatoid arthritis.
Drug-Drug: Inform your doctor about other medications.
Drug-Food: Avoid caffeine-containing drinks.
Pregnancy category X. Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in pregnant women outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
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